Shaun’s proposed treatment for a homeless patient puts him and Dr. Kalu in Dr. Andrews' crosshairs. Claire tries to overcome Dr. Melendez's reluctance to do a risky heart operation. Dr. Glassman faces a difficult decision about his health.
- Freddie Highmore as Dr. Shaun Murphy
- Nicholas Gonzalez as Dr. Neil Melendez
- Antonia Thomas as Dr. Claire Browne
- Chuku Modu as Dr. Jared Kalu
- Tamlyn Tomita as Allegra Aoki
- Will Yun Lee as Dr. Alex Park
- Fiona Gubelmann as Dr. Morgan Reznick
- Christina Chang as Dr. Audrey Lim
- Paige Spara as Lea Dilallo
- Hill Harper as Dr. Marcus Andrews
- Richard Schiff as Dr. Aaron Glassman
- Lisa Edelstein as Dr. Blaize
- Raphael Sbarge as Edward Thomas
- Will Yun Lee, Fiona Gubelmann, Christina Chang and Paige Spara are promoted to series regulars.
- This marks Chuku Modu's final appearance as a series regular.