Dr. Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join the prestigious St. Bonaventure Hospital's surgical unit. Alone in the world and unable to personally connect with those around him, his only advocate, Dr. Aaron Glassman, challenges the skepticism and prejudices of the hospital's board and staff when he brings him in to join the team. Shaun will need to work harder than he ever has before, as he navigates his new environment and relationships to prove to his colleagues that his extraordinary medical gifts will save lives.
On the way to his job interview at the San Jose St. Bonaventure Hospital, Dr. Shaun Murphy encounters a boy injured when a glass fixture shatters and falls on him and jumps in to assist, his unique perspective on the world guiding him through the procedure. He also helps another doctor who is there, by instructing him on how to stop the boy from dying. On the way to the hospital, Shaun notices that the boy’s vitals have changed, and argues that something is wrong, but no one believes him. Dr. Aaron Glassman, president at the hospital, tries to convince the board to hire Shaun despite his autism, while Dr. Marcus Andrews fights against him. Dr. Claire Browne tries to prove herself to her overconfident superior Dr. Neil Melendez. The doctors realizes that Shaun is right, and asks for assistance in saving the boy's life, which they do. During his childhood, Shaun suffers due to an abusive father and bullies at school, but is protected and assisted by his younger brother, Steve, until tragedy strikes.
- While making the one-way valve, Dr. Shaun Murphy says water instead of alcohol when referring to the liquid in the whiskey bottle.
- This marks the only appearance of Irene Keng as a series regular.